Sildenafil therapy for Pulmonary Hypertension and Sickle Cell Disease

Sildenafil therapy for Pulmonary Hypertension and Sickle Cell Disease

Issue:  Pulmonary hypertension, a common complication of SCD, heralds a serious risk of early death in affected patients.  Can treatment with sildenafil improve functioning and increase survival?  

Participants:  Persons with SCD, 12 years of age or older, who have at least mild pulmonary hypertension

Comparison:   sildenafil (the experimental treatment)

versus

placebo (the control)

More information:  http://www.clinicaltrials.gov/ct2/show/NCT00492531